|Application ||WB, IHC-P, E|
|Calculated MW||9888 Da|
|Antigen Region||63-89 aa|
|Other Names||Cornifin-B, 149 kDa pancornulin, Small proline-rich protein IB, SPR-IB, SPRR1B|
|Target/Specificity||This SPRR1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-89 amino acids from the C-terminal region of human SPRR1B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPRR1B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage.|
|Tissue Location||Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea|
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Provided below are standard protocols that you may find useful for product applications.
SPRR1B is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross-linkage.
Stemmler,S., et.al., Int. J. Immunogenet. 36 (4), 217-222 (2009)
Kainu,K., et.al., Exp. Dermatol. 18 (2), 109-115 (2009)
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