|Application ||WB, IHC-P, FC, E|
|Calculated MW||53900 Da|
|Antigen Region||293-324 aa|
|Other Names||Bactericidal permeability-increasing protein, BPI, CAP 57, BPI|
|Target/Specificity||This BPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-324 amino acids from the Central region of human BPI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||BPI Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.|
|Cellular Location||Secreted. Cytoplasmic granule membrane Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.|
|Tissue Location||Restricted to cells of the myeloid series.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
BPI encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms.
Davila,S., et.al., Genes Immun. (2010) In press
Guey,L.T., et.al., Eur. Urol. 57 (2), 283-292 (2010)
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