|Application ||WB, IHC-P, FC, E|
|Calculated MW||53900 Da|
|Antigen Region||293-324 aa|
|Other Names||Bactericidal permeability-increasing protein, BPI, CAP 57, BPI|
|Target/Specificity||This BPI antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 293-324 amino acids from the Central region of human BPI.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Precautions||BPI Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa.|
|Cellular Location||Secreted. Cytoplasmic granule membrane Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules.|
|Tissue Location||Restricted to cells of the myeloid series.|
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Provided below are standard protocols that you may find useful for product applications.
BPI encodes a lipopolysaccharide binding protein. It is associated with human neutrophil granules and has bactericidal activity on gram-negative organisms.
Davila,S., et.al., Genes Immun. (2010) In press
Guey,L.T., et.al., Eur. Urol. 57 (2), 283-292 (2010)
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