|Application ||WB, IHC-P, E|
|Calculated MW||99351 Da|
|Antigen Region||816-842 aa|
|Other Names||Microsomal triglyceride transfer protein large subunit, MTTP, MTP|
|Target/Specificity||This MTTP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 816-842 amino acids from the C-terminal region of human MTTP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MTTP Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:23475612, PubMed:8939939, PubMed:26224785, PubMed:25108285, PubMed:22236406). Required for the secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:23475612, PubMed:8939939, PubMed:26224785).|
|Cellular Location||Endoplasmic reticulum. Note=Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785)|
|Tissue Location||Liver and small intestine. Also found in ovary, testis and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
MTTP encodes the large subunit of the heterodimeric microsomal triglyceride transfer protein. Protein disulfide isomerase (PDI) completes the heterodimeric microsomal triglyceride transfer protein, which has been shown to play a entral role in lipoprotein assembly. Mutations in MTP can cause abetalipoproteinemia.
Dai,K., et.al., Arterioscler. Thromb. Vasc. Biol. 30 (3), 568-574 (2010)
Oliveira,C.P., et.al., J. Gastroenterol. Hepatol. 25 (2), 357-361 (2010)
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