|Application ||WB, IHC-P, E|
|Calculated MW||45847 Da|
|Antigen Region||387-416 aa|
|Other Names||Acrosin, Acrosin light chain, Acrosin heavy chain, ACR, ACRS|
|Target/Specificity||This ACR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 387-416 amino acids from the C-terminal region of human ACR.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACR Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome.|
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Provided below are standard protocols that you may find useful for product applications.
ACR is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids.
Dube,C., et.al., J. Androl. 26 (4), 519-528 (2005)
Furlong,L.I., et.al., Fertil. Steril. 83 (6), 1791-1796 (2005)
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