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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CDC14B Antibody (Center)   

CDC14B Antibody (Center)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CDC14B Antibody (Center) AP9081c
    Western blot analysis of CDC14B Antibody (Center) (Cat. #AP9081c) in 293 cell line lysates (35ug/lane). CDC14B (arrow) was detected using the purified Pab.
  • FC - CDC14B Antibody (Center) AP9081c
    CDC14B Antibody (Center) (Cat. #AP9081c) flow cytometry analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O60729
Other Accession A4D256, Q6PFY9
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 56802 Da
Antigen Region 188-215 aa
Additional Information
Gene ID 8555
Other Names Dual specificity protein phosphatase CDC14B, CDC14 cell division cycle 14 homolog B, CDC14B
Target/Specificity This CDC14B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 188-215 amino acids from the Central region of human CDC14B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCDC14B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CDC14B
Function Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases.
Cellular Location Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1
Research Areas
Citations (0)

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CDC14B is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.


Bassermann,F.,, Cell 134 (2), 256-267 (2008)
Rosso,L.,, PLoS Biol. 6 (6), E140 (2008)

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$ 295.00
$ 99.00
Cat# AP9081c
(40 western blots)
Availability: In Stock
Bulk Size
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