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TNFRSF14 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TNFRSF14 Antibody (Center) AP9094c
    Western blot analysis of anti-TNFRSF14 Antibody (Center) Pab (Cat. #AP9094c) pre-incubated without(lane 1) and with(lane 2) blocking peptide in HL-60 cell line lysate. TNFRSF14 (arrow) was detected using the purified Pab.
  • IHC-P - TNFRSF14 Antibody (Center) AP9094c
    Formalin-fixed and paraffin-embedded human lung carcinoma reacted with TNFRSF14 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - TNFRSF14 Antibody (Center) AP9094c
    TNFRSF14 Antibody (Center) (Cat. #AP9094c) flow cytometric analysis of HL-60 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q92956
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 30392 Da
Antigen Region 210-236 aa
Additional Information
Gene ID 8764
Other Names Tumor necrosis factor receptor superfamily member 14, Herpes virus entry mediator A, Herpesvirus entry mediator A, HveA, Tumor necrosis factor receptor-like 2, TR2, CD270, TNFRSF14, HVEA, HVEM
Target/Specificity This TNFRSF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 210-236 amino acids from the Central region of human TNFRSF14.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTNFRSF14 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HVEA, HVEM
Function Receptor for BTLA. Receptor for TNFSF14/LIGHT and homotrimeric TNFSF1/lymphotoxin-alpha. Involved in lymphocyte activation. Plays an important role in HSV pathogenesis because it enhanced the entry of several wild-type HSV strains of both serotypes into CHO cells, and mediated HSV entry into activated human T-cells.
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed, with the highest expression in lung, spleen and thymus
Research Areas
Citations (0)

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TNFRSF14 is a member of the TNF-receptor superfamily. This receptor was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to this receptor protein has been shown to be part of the viral entry mechanism. The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response.


Dubois,P.C.,, Nat. Genet. 42 (4), 295-302 (2010)
Davila,S.,, Genes Immun. (2010) In press

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Cat# AP9094c
(40 western blots)
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