|Application ||WB, FC, E|
|Other Accession||Q03061, P27699, Q1LZH5|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||38940 Da|
|Antigen Region||287-314 aa|
|Other Names||cAMP-responsive element modulator, Inducible cAMP early repressor, ICER, CREM|
|Target/Specificity||This CREM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 287-314 amino acids from the C-terminal region of human CREM.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CREM Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550).|
|Tissue Location||Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes|
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Provided below are standard protocols that you may find useful for product applications.
CREM is a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes.
Fujimoto,T., et.al., J. Biochem. 115 (2), 298-303 (1994)
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