|Application ||WB, IHC-P, FC, E|
|Other Accession||P48032, O97590, P39876, P61269, P79121, Q9TUL9|
|Predicted||Bovine, Monkey, Rabbit, Rat|
|Calculated MW||24145 Da|
|Antigen Region||113-139 aa|
|Other Names||Metalloproteinase inhibitor 3, Protein MIG-5, Tissue inhibitor of metalloproteinases 3, TIMP-3, TIMP3|
|Target/Specificity||This TIMP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-139 amino acids from the Central region of human TIMP3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TIMP3 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
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Provided below are standard protocols that you may find useful for product applications.
TIMP3 is one of inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM).
Jacobson,S.G., et.al., Nat. Genet. 11 (1), 27-32 (1995) Wick,M., et.al., Biochem. J. 311 (PT 2), 549-554 (1995)
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