|Application ||WB, FC, IF, E|
|Calculated MW||60069 Da|
|Antigen Region||341-367 aa|
|Other Names||A/G-specific adenine DNA glycosylase, 322-, MutY homolog, hMYH, MUTYH, MYH|
|Target/Specificity||This MUTYH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-367 amino acids from the Central region of human MUTYH.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MUTYH Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities.|
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Provided below are standard protocols that you may find useful for product applications.
MYH is the eukaryotic homolog to the E. coli protein MutY. It was first identified in HeLa cells and nicks DNA replication errors, specifically A/G mismatches. MYH is involved in oxidative DNA damage repair. It initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. It possesses both adenine and 2-OH-A DNA glycosylase activities.
Kim C.J., et.al., Oncogene 23:6820-6822(2004).
Isidro G., et.al., Hum. Mutat. 24:353-354(2004).
Sieber O.M., et.al., N. Engl. J. Med. 348:791-799(2003).
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