|Application ||WB, E|
|Calculated MW||92949 Da|
|Antigen Region||191-220 aa|
|Other Names||Ecotropic viral integration site 5 protein homolog, EVI-5, Neuroblastoma stage 4S gene protein, EVI5, NB4S|
|Target/Specificity||This EVI5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-220 amino acids from the N-terminal region of human EVI5.|
|Precautions||EVI5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis|
|Tissue Location||Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.|
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Provided below are standard protocols that you may find useful for product applications.
EVI5 is a novel centrosomal protein with a complex expression pattern and subcellular localization, possibly involved in centrosome stability and dynamics. It may act as an oncogene.
Jacob,B., et.al., Blood 115 (8), 1610-1620 (2010)
Hoppenbrouwers,I.A., et.al., J. Hum. Genet. 54 (11), 676-680 (2009)
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