|Application ||WB, E|
|Calculated MW||92949 Da|
|Antigen Region||191-220 aa|
|Other Names||Ecotropic viral integration site 5 protein homolog, EVI-5, Neuroblastoma stage 4S gene protein, EVI5, NB4S|
|Target/Specificity||This EVI5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-220 amino acids from the N-terminal region of human EVI5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||EVI5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.|
|Cellular Location||Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis|
|Tissue Location||Expressed in various cell lines (at protein level). Expressed in a wide range of tissues including brain and adrenal.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
EVI5 is a novel centrosomal protein with a complex expression pattern and subcellular localization, possibly involved in centrosome stability and dynamics. It may act as an oncogene.
Jacob,B., et.al., Blood 115 (8), 1610-1620 (2010)
Hoppenbrouwers,I.A., et.al., J. Hum. Genet. 54 (11), 676-680 (2009)
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