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KCNH7 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KCNH7 Antibody (N-term) AP9169a
    Western blot analysis of KCNH7 Antibody (N-term) (Cat. #AP9169a) in T47D cell line lysates (35ug/lane). KCNH7 (arrow) was detected using the purified Pab.
    detail
  • IHC-P - KCNH7 Antibody (N-term) AP9169a
    Formalin-fixed and paraffin-embedded human brain tissue reacted with KCNH7 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
    detail
  • FC - KCNH7 Antibody (N-term) AP9169a
    KCNH7 Antibody (N-term) (Cat. #AP9169a) flow cytometric analysis of HepG2 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, IHC-P, WB, E
Primary Accession Q9NS40
Other Accession O54852, Q9ER47
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 135000 Da
Antigen Region 52-78 aa
Additional Information
Gene ID 90134
Other Names Potassium voltage-gated channel subfamily H member 7, Ether-a-go-go-related gene potassium channel 3, ERG-3, Eag-related protein 3, Ether-a-go-go-related protein 3, hERG-3, Voltage-gated potassium channel subunit Kv113, KCNH7, ERG3
Target/Specificity This KCNH7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-78 amino acids from the N-terminal region of human KCNH7.
Dilution WB~~1:1000
IHC-P~~1:50~100
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKCNH7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KCNH7
Synonyms ERG3
Function Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly.
Cellular Location Membrane; Multi-pass membrane protein.
Tissue Location Expressed in prolactin-secreting adenomas.
Citations (0)
citation

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Background

KCNH7 represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This protein encodes a member of the potassium channel, voltage-gated, subfamily H.

References

Alkelai,A., et.al., Psychopharmacology (Berl.) 206 (3), 491-499 (2009)
Couturier,N., et.al., Eur. J. Hum. Genet. 17 (6), 844-847 (2009)

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$ 182.50
$ 70.00
Cat# AP9169a
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