SLC25A17 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, WB, E |
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Primary Accession | O43808 |
Other Accession | O70579 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 34567 Da |
Antigen Region | 17-44 aa |
Gene ID | 10478 |
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Other Names | Peroxisomal membrane protein PMP34, 34 kDa peroxisomal membrane protein, Solute carrier family 25 member 17, SLC25A17, PMP34 |
Target/Specificity | This SLC25A17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-44 amino acids from the N-terminal region of human SLC25A17. |
Dilution | WB~~1:1000 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC25A17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC25A17 {ECO:0000303|PubMed:22185573, ECO:0000312|HGNC:HGNC:10987} |
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Function | Peroxisomal transporter for multiple cofactors like coenzyme A (CoA), flavin adenine dinucleotide (FAD), flavin mononucleotide (FMN) and nucleotide adenosine monophosphate (AMP), and to a lesser extent for nicotinamide adenine dinucleotide (NAD(+)), adenosine diphosphate (ADP) and adenosine 3',5'-diphosphate (PAP). May catalyze the transport of free CoA, FAD and NAD(+) from the cytosol into the peroxisomal matrix by a counter-exchange mechanism. |
Cellular Location | Cytoplasm. Peroxisome membrane; Multi-pass membrane protein |
Tissue Location | Ubiquitous. Expressed in liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This protein encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Studies suggest that this protein may regulate cytokine production, and thus play a key role in the control of the inflammatory response.
References
McGeachie,M., et.al., Circulation 120 (24), 2448-2454 (2009)
Kelly,E., et.al., J. Biol. Chem. 284 (25), 16891-16897 (2009)
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