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DCP2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DCP2 Antibody (Center) AP9182c
    Western blot analysis of DCP2 Antibody (Center) (Cat. #AP9182c) in HL-60 cell line lysates (35ug/lane). DCP2 (arrow) was detected using the purified Pab.
  • IHC-P - DCP2 Antibody (Center) AP9182c
    DCP2 Antibody (Center) (Cat. #AP9182c) IHC analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the DCP2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - DCP2 Antibody (Center) AP9182c
    DCP2 Antibody (Center) (Cat. #AP9182c) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8IU60
Other Accession Q9CYC6
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 48457 Da
Antigen Region 144-173 aa
Additional Information
Gene ID 167227
Other Names m7GpppN-mRNA hydrolase, Nucleoside diphosphate-linked moiety X motif 20, Nudix motif 20, mRNA-decapping enzyme 2, hDpc, DCP2, NUDT20
Target/Specificity This DCP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 144-173 amino acids from the Central region of human DCP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDCP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DCP2
Synonyms NUDT20
Function Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.
Cellular Location Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, in processing bodies (PB). A minor amount is nuclear
Tissue Location Expressed in brain and testis. Not detected in heart (at protein level).
Citations (0)

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DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).


Yamochi,T.,, Biochem. Biophys. Res. Commun. 370 (1), 195-199 (2008)
Li,Y.,, Mol. Cell. Biol. 28 (3), 939-948 (2008)

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Cat# AP9182c
(40 western blots)
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