|Application ||WB, IHC-P, FC, IF, E|
|Calculated MW||42674 Da|
|Antigen Region||336-364 aa|
|Other Names||Protein DEK, DEK|
|Target/Specificity||This DEK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-364 amino acids from the C-terminal region of human DEK.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DEK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in chromatin organization.|
|Cellular Location||Nucleus. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei|
|Tissue Location||Ubiquitous. Expressed at relatively high levels|
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Provided below are standard protocols that you may find useful for product applications.
DEK is a protein with one SAP domain. This protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA, and is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region, increased expression of this gene, and the presence of antibodies against this protein are all associated with various diseases.
Sawatsubashi,S., et.al., Genes Dev. 24 (2), 159-170 (2010)
Khodadoust,M.S., et.al., Cancer Res. 69 (16), 6405-6413 (2009)
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