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>   home   >   Products   >   Primary Antibodies   >   FBXO3 Antibody (C-term)   

FBXO3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FBXO3 Antibody (C-term) AP9195b
    Western blot analysis of FBXO3 Antibody (C-term) (Cat. #AP9195b) in HepG2 cell line lysates (35ug/lane). FBXO3 (arrow) was detected using the purified Pab.
  • FC - FBXO3 Antibody (C-term) AP9195b
    FBXO3 Antibody (C-term) (Cat. #AP9195b) flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UK99
Other Accession D4ABP9, Q9DC63, A6H7H7
Reactivity Human
Predicted Bovine, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54561 Da
Antigen Region 395-422 aa
Additional Information
Gene ID 26273
Other Names F-box only protein 3, FBXO3, FBX3
Target/Specificity This FBXO3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-422 amino acids from the C-terminal region of human FBXO3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXO3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO3
Synonyms FBX3
Function Substrate recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53- dependent transactivation.
Cellular Location Nucleus. Note=Colocalizes with PML at the peripheries of nuclear bodies
Citations (0)

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FBXO3 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs.


Shima,Y.,, Mol. Cell. Biol. 28 (23), 7126-7138 (2008)
Ilyin,G.P.,, Genomics 67 (1), 40-47 (2000)

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$ 295.00
$ 99.00
Cat# AP9195b
(40 western blots)
Availability: In Stock
Bulk Size
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