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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   ALOX15B Antibody (C-term)   

ALOX15B Antibody (C-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • WB - ALOX15B Antibody (C-term) AP9200b
    Western blot analysis of ALOX15B Antibody (C-term) (Cat. #AP9200b) in CEM cell line lysates (35ug/lane). ALOX15B (arrow) was detected using the purified Pab.
  • IHC-P - ALOX15B Antibody (C-term) AP9200b
    Formalin-fixed and paraffin-embedded human skin tissue reacted with ALOX15B Antibody (C-term) (Cat. #AP9200b),which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O15296
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 75857 Da
Antigen Region 597-627 aa
Additional Information
Gene ID 247
Other Names Arachidonate 15-lipoxygenase B, 15-LOX-B, 15-lipoxygenase 2, 15-LOX-2, Arachidonate 15-lipoxygenase type II, Linoleate 13-lipoxygenase 15-LOb, 11311-, ALOX15B
Target/Specificity This ALOX15B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 597-627 amino acids from the C-terminal region of human ALOX15B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsALOX15B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name ALOX15B
Function Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid/(15S)-HPETE. Also acts on linoleic acid to produce 13-hydroxyoctadecadienoic acid/13-HPODE. Has no detectable 8S-lipoxygenase activity but reacts with (8S)- HPETE to produce (8S,15S)-diHPETE. May regulate progression through the cell cycle and cell proliferation. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response. May also regulate macrophage differentiation into proatherogenic foam cells.
Cellular Location Isoform A: Nucleus. Note=Other isoforms are excluded from the nucleus
Tissue Location Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.
Research Areas
Citations (0)

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ALOX15B encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17.


Wecksler,A.T.,, Biochemistry 48 (36), 8721-8730 (2009)
Kawakami,Y.,, Biosci. Biotechnol. Biochem. 73 (8), 1811-1817 (2009)

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$ 295.00
$ 99.00
Cat# AP9200b
(40 western blots)
Availability: In Stock
Bulk Size
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