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>   home   >   Products   >   Primary Antibodies   >   Immunology   >   KIR3DL2 Antibody (N-term)   

KIR3DL2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - KIR3DL2 Antibody (N-term) AP9215A
    Western blot analysis of KIR3DL2 Antibody (N-term) (Cat. #AP9215a) in HL-60 cell line lysates (35ug/lane). KIR3DL2 (arrow) was detected using the purified Pab.
  • FC - KIR3DL2 Antibody (N-term) AP9215A
    KIR3DL2 Antibody (N-term) (Cat. #AP9215a) flow cytometric analysis of HL-60 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, FC, E
Primary Accession P43630
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 50230 Da
Antigen Region 46-74 aa
Additional Information
Gene ID 3812
Other Names Killer cell immunoglobulin-like receptor 3DL2, CD158 antigen-like family member K, MHC class I NK cell receptor, Natural killer-associated transcript 4, NKAT-4, p70 natural killer cell receptor clone CL-5, p70 NK receptor CL-5, CD158k, KIR3DL2, CD158K, NKAT4
Target/Specificity This KIR3DL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 46-74 amino acids from the N-terminal region of human KIR3DL2.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKIR3DL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KIR3DL2
Synonyms CD158K, NKAT4
Function Receptor on natural killer (NK) cells for HLA-A alleles. Inhibits the activity of NK cells thus preventing cell lysis.
Cellular Location Cell membrane; Single-pass type I membrane protein
Research Areas
Citations (0)

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Background

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals.

References

Pende,D., et.al, J. Exp. Med. 184 (2), 505-518 (1996)
Dohring,C., et.al, Immunogenetics 44 (3), 227-230 (1996)

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Discontinued
Cat# AP9215A
Size:
(40 western blots)

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