- CITATIONS: 1
|Application ||WB, FC, E|
|Calculated MW||24845 Da|
|Antigen Region||140-166 aa|
|Other Names||Claudin-8, CLDN8|
|Target/Specificity||This CLDN8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 140-166 amino acids from the Central region of human CLDN8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLDN8 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a major role in tight junction-specific obliteration of the intercellular space.|
|Cellular Location||Cell junction, tight junction. Cell membrane; Multi-pass membrane protein. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells|
|Tissue Location||Expressed in the epididymis, mainly in the caput segment.|
Provided below are standard protocols that you may find useful for product applications.
CLDN8 is components of epithelial cell tight junctions. Tight junctions regulate movement of solutes and ions through the paracellular space and prevent mixing of proteins and lipids in the outer leaflet of the apical and basolateral plasma membrane domains
Kim,S.S., et.al., Histopathology 54 (5), 633-635 (2009)
Osunkoya,A.O., et.al, Hum. Pathol. 40 (2), 206-210 (2009)
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