|Application ||WB, E|
|Calculated MW||28879 Da|
|Antigen Region||191-217 aa|
|Other Names||Uroplakin-1a, UP1a, Tetraspanin-21, Tspan-21, Uroplakin Ia, UPIa, UPKa, UPK1A, TSPAN21|
|Target/Specificity||This UPK1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 191-217 amino acids from the C-terminal region of human UPK1A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UPK1A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||High expression restricted to ureteric urothelium (most superficial cells); low expression in prostate Expression in normal urothelial cells is lost in culture. Some expression in tumor cell lines derived from urothelial malignancies.|
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Provided below are standard protocols that you may find useful for product applications.
The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
Wang,H., et.al., J. Mol. Biol. 392 (2), 352-361 (2009)
Hall,G.D., et.al., Biochim. Biophys. Acta 1729 (2), 126-134 (2005)
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