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EXTL2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UBQ6 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 37466 Da |
| Antigen Region | 269-295 aa |
| Gene ID | 2135 |
|---|---|
| Other Names | Exostosin-like 2, Alpha-1, 4-N-acetylhexosaminyltransferase EXTL2, Alpha-GalNAcT EXTL2, EXT-related protein 2, Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase, Processed exostosin-like 2, EXTL2, EXTR2 |
| Target/Specificity | This EXTL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 269-295 amino acids from the C-terminal region of human EXTL2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | EXTL2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | EXTL2 |
|---|---|
| Synonyms | EXTR2 |
| Function | Glycosyltransferase required for the biosynthesis of heparan- sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains. |
| Cellular Location | Endoplasmic reticulum membrane; Single-pass type II membrane protein |
| Tissue Location | Ubiquitous. |
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Provided below are standard protocols that you may find useful for product applications.
Background
EXTL2 is a glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
References
Kaidonis,X., et.al, Eur. J. Hum. Genet. 18 (2), 194-199 (2010)
Sobhany,M., et.al, J. Biol. Chem. 280 (25), 23441-23445 (2005)
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