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MEF2A Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - MEF2A Antibody (Center) AP9258c
    Western blot analysis of MEF2A Antibody (Center) (Cat. #AP9258c) in mouse brain tissue lysates (35ug/lane). MEF2A (arrow) was detected using the purified Pab.
  • IHC-P - MEF2A Antibody (Center) AP9258c
    MEF2A Antibody (Center) (Cat. #AP9258c) immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the MEF2A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • IF - MEF2A Antibody (Center) AP9258c
    Confocal immunofluorescent analysis of MEF2A Antibody (Center)(Cat. #AP9258c) with Hela cell followed by Alexa Fluor® 488-conjugated goat anti-rabbit lgG (green). DAPI was used to stain the cell nuclear (blue).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02078
Other Accession Q2MJT0, A2ICN5, Q60929, A2VDZ3
Reactivity Human, Mouse
Predicted Rat, Pig, Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 54811 Da
Antigen Region 453-479 aa
Additional Information
Gene ID 4205
Other Names Myocyte-specific enhancer factor 2A, Serum response factor-like protein 1, MEF2A, MEF2
Target/Specificity This MEF2A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-479 amino acids from the Central region of human MEF2A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMEF2A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name MEF2A
Synonyms MEF2
Function Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:16563226}
Tissue Location Isoform MEF2 and isoform MEFA are expressed only in skeletal and cardiac muscle and in the brain. Isoform RSRFC4 and isoform RSRFC9 are expressed in all tissues examined
Research Areas
Citations (0)

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MEF2A is a DNA-binding transcription factor that activates many muscle-specific, growth factor-induced, and stress-induced genes. The encoded protein can act as a homodimer or as a heterodimer and is involved in several cellular processes, including muscle development, neuronal differentiation, cell growth control, and apoptosis. Defects in this protein could be a cause of autosomal dominant coronary artery disease 1 with myocardial infarction (ADCAD1).


Wu,Y.,, J. Mol. Biol. 397 (2), 520-533 (2010)
Ishikawa,F.,, Oncogene 29 (6), 909-919 (2010)

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Cat# AP9258c
(40 western blots)
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