|Application ||WB, IHC-P, E|
|Calculated MW||68297 Da|
|Antigen Region||539-568 aa|
|Other Names||Actin-related protein 5, hARP5, Sarcoma antigen NY-SAR-16, ACTR5, ARP5|
|Target/Specificity||This ACTR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 539-568 amino acids from the C-terminal region of human ACTR5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACTR5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair.|
|Cellular Location||Nucleus Cytoplasm. Note=Predominantly nuclear but undergoes nucleo-cytoplasmic shuttling (PubMed:19014934). Localized to interphase nuclei, but not nucleoli; excluded from chromosomes as mitosis progresses (PubMed:18163988)|
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Provided below are standard protocols that you may find useful for product applications.
ACTR5 may be involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex
Kitayama,K., et.al., Exp. Cell Res. 315 (2), 206-217 (2009)
Jin,J., et.al., J. Biol. Chem. 280 (50), 41207-41212 (2005)
Lee,S.Y., et.al., Proc. Natl. Acad. Sci. U.S.A. 100 (5), 2651-2656 (2003)
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