|Application ||WB, IHC-P, FC, E|
|Calculated MW||35701 Da|
|Antigen Region||242-269 aa|
|Other Names||BTB/POZ domain-containing protein KCTD12, Pfetin, Predominantly fetal expressed T1 domain, KCTD12, C13orf2, KIAA1778, PFET1|
|Target/Specificity||This KCTD12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 242-269 amino acids from the Central region of human KCTD12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KCTD12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||C13orf2, KIAA1778, PFET1|
|Function||Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).|
|Cellular Location||Cell junction, synapse, presynaptic cell membrane. Cell junction, synapse, postsynaptic cell membrane|
|Tissue Location||Present in a variety of fetal organs, with highest expression levels in the cochlea and brain and, in stark contrast, is detected only at extremely low levels in adult organs, such as brain and lung.|
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Provided below are standard protocols that you may find useful for product applications.
Drenos,F., et.al., Hum. Mol. Genet. 18 (12), 2305-2316 (2009) Suehara,Y., et.al., Clin. Cancer Res. 14 (6), 1707-1717 (2008) Cauchi,S., et.al., J. Mol. Med. 86 (3), 341-348 (2008)
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