|Application ||WB, E|
|Other Accession||Q8CHQ0, Q3T0J1|
|Calculated MW||44136 Da|
|Antigen Region||225-251 aa|
|Other Names||F-box only protein 4, FBXO4, FBX4|
|Target/Specificity||This FBXO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-251 amino acids from the Central region of human FBXO4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXO4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1.|
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Provided below are standard protocols that you may find useful for product applications.
FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbxs class.
Zeng,Z., et.al., Dev. Cell 18 (2), 214-225 (2010)
Barbash,O., et.al., Cancer Cell 14 (1), 68-78 (2008)
Sugiyama,N., et.al., Mol. Cell Proteomics 6 (6), 1103-1109 (2007)
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