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FBXO4 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - FBXO4 Antibody (Center) AP9295c
    Western blot analysis of FBXO4 Antibody (Center) (Cat. #AP9295c) in Y79 cell line lysates (35ug/lane). FBXO4 (arrow) was detected using the purified Pab.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9UKT5
Other Accession Q8CHQ0, Q3T0J1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 44136 Da
Antigen Region 225-251 aa
Additional Information
Gene ID 26272
Other Names F-box only protein 4, FBXO4, FBX4
Target/Specificity This FBXO4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 225-251 amino acids from the Central region of human FBXO4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXO4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXO4
Synonyms FBX4
Function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18598945, PubMed:10531035, PubMed:29142209, PubMed:20181953). Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation (PubMed:18598945). Recognizes TERF1 and promotes its ubiquitination together with UBE2D1 (PubMed:16275645, PubMed:20159592). Promotes ubiquitination of FXR1 following phosphorylation of FXR1 by GSK3B, leading to FXR1 degradation by the proteasome (PubMed:29142209).
Cellular Location Cytoplasm {ECO:0000250|UniProtKB:Q8CHQ0}.
Research Areas
Citations (0)
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Background

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbxs class.

References

Zeng,Z., et.al., Dev. Cell 18 (2), 214-225 (2010)
Barbash,O., et.al., Cancer Cell 14 (1), 68-78 (2008)
Sugiyama,N., et.al., Mol. Cell Proteomics 6 (6), 1103-1109 (2007)

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$ 182.50
$ 70.00
Cat# AP9295c
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