|Application ||WB, IHC-P, FC, E|
|Other Accession||P23576, P26048, P10063|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||51326 Da|
|Antigen Region||378-406 aa|
|Other Names||Gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2, GABRA2|
|Target/Specificity||This GABRA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 378-406 amino acids from the C-terminal region of human GABRA2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GABRA2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
GABRA2 is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.
Das,S., et.al., Stat Med 29 (11), 1250-1258 (2010)
Bierut,L.J., et.al., Proc. Natl. Acad. Sci. U.S.A. 107 (11), 5082-5087 (2010)
Dixon,C.I., et.al., Proc. Natl. Acad. Sci. U.S.A. 107 (5), 2289-2294 (2010)
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