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GABRA4 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GABRA4 Antibody (Center) AP9298c
    Western blot analysis of GABRA4 Antibody (Center) (Cat. #AP9298c) in CEM cell line lysates (35ug/lane). GABRA4 (arrow) was detected using the purified Pab.
  • IHC-P - GABRA4 Antibody (Center) AP9298c
    GABRA4 Antibody (Center) (Cat. #AP9298c) IHC analysis in formalin fixed and paraffin embedded brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the GABRA4 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
  • FC - GABRA4 Antibody (Center) AP9298c
    GABRA4 Antibody (Center) (Cat. #AP9298c) flow cytometric analysis of CEM cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P48169
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 61623 Da
Antigen Region 350-377 aa
Additional Information
Gene ID 2557
Other Names Gamma-aminobutyric acid receptor subunit alpha-4, GABA(A) receptor subunit alpha-4, GABRA4
Target/Specificity This GABRA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-377 amino acids from the Central region of human GABRA4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGABRA4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Cellular Location Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein
Research Areas
Citations (0)

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GABRA4 is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.


Guilmatre,A.,, Arch. Gen. Psychiatry 66 (9), 947-956 (2009)
Maldonado-Aviles,J.G.,, Am J Psychiatry 166 (4), 450-459 (2009)
Agrawal,A.,, Addiction 104 (3), 471-477 (2009)

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Cat# AP9298c
(40 western blots)
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