|Application ||WB, FC, E|
|Calculated MW||61623 Da|
|Antigen Region||350-377 aa|
|Other Names||Gamma-aminobutyric acid receptor subunit alpha-4, GABA(A) receptor subunit alpha-4, GABRA4|
|Target/Specificity||This GABRA4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 350-377 amino acids from the Central region of human GABRA4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GABRA4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.|
|Cellular Location||Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
GABRA4 is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor.
Guilmatre,A., et.al., Arch. Gen. Psychiatry 66 (9), 947-956 (2009)
Maldonado-Aviles,J.G., et.al., Am J Psychiatry 166 (4), 450-459 (2009)
Agrawal,A., et.al., Addiction 104 (3), 471-477 (2009)
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