|Application ||WB, FC, E|
|Calculated MW||17840 Da|
|Antigen Region||80-108 aa|
|Other Names||Ribonuclease H2 subunit C, RNase H2 subunit C, Aicardi-Goutieres syndrome 3 protein, AGS3, RNase H1 small subunit, Ribonuclease HI subunit C, RNASEH2C, AYP1|
|Target/Specificity||This RNH2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-108 amino acids from the Central region of human RNH2C.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RNH2C Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging- strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
RNH2C encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes.
Chon,H., et.al., Nucleic Acids Res. 37 (1), 96-110 (2009)
Rice,G., et.al., Am. J. Hum. Genet. 81 (4), 713-725 (2007)
Crow,Y.J., et.al., Nat. Genet. 38 (8), 910-916 (2006)
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