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>   home   >   Products   >   Primary Antibodies   >   CENPK Antibody (C-term)   

CENPK Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CENPK Antibody (C-term) AP9316b
    Western blot analysis of CENPK Antibody (C-term) (Cat. #AP9316b) in mouse liver tissue lysates (35ug/lane). CENPK (arrow) was detected using the purified Pab.
  • IHC-P - CENPK Antibody (C-term) AP9316b
    Formalin-fixed and paraffin-embedded human brain tissue reacted with CENPK Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q9BS16
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31655 Da
Antigen Region 239-266 aa
Additional Information
Gene ID 64105
Other Names Centromere protein K, CENP-K, Interphase centromere complex protein 37, Protein AF-5alpha, p33, CENPK, ICEN37
Target/Specificity This CENPK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-266 amino acids from the C-terminal region of human CENPK.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCENPK Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CENPK
Synonyms ICEN37
Function Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore.
Cellular Location Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex
Tissue Location Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta.
Citations (0)

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Background

CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression.

References

Cheeseman,I.M., et.al., Mol. Biol. Cell 19 (2), 587-594 (2008)
Izuta,H., et.al., Genes Cells 11 (6), 673-684 (2006)
Okada,M., et.al., Nat. Cell Biol. 8 (5), 446-457 (2006)

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Cat# AP9316b
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(40 western blots)
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