PARVA Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| IHC-P, WB, E |
---|---|
Primary Accession | Q9NVD7 |
Other Accession | Q9HB97, Q9EPC1 |
Reactivity | Human, Mouse |
Predicted | Rat |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 42244 Da |
Antigen Region | 323-351 aa |
Gene ID | 55742 |
---|---|
Other Names | Alpha-parvin, Actopaxin, CH-ILKBP, Calponin-like integrin-linked kinase-binding protein, Matrix-remodeling-associated protein 2, PARVA, MXRA2 |
Target/Specificity | This PARVA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-351 amino acids from the C-terminal region of human PARVA. |
Dilution | WB~~1:1000 IHC-P~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PARVA Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PARVA |
---|---|
Synonyms | MXRA2 |
Function | Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. |
Cellular Location | Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton Cytoplasm, myofibril, sarcomere, Z line. Note=Constituent of focal adhesions. Associates with the actin cytoskeleton |
Tissue Location | Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver. |
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Provided below are standard protocols that you may find useful for product applications.
Background
PARVA is members of the parvin family, including PARVA, are actin-binding proteins associated with focal contacts.
References
Lorenz,S., et.al., Structure 16 (10), 1521-1531 (2008)
Wang,X., et.al., J. Biol. Chem. 283 (30), 21113-21119 (2008)
Ewing,R.M., et.al., Mol. Syst. Biol. 3, 89 (2007)
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