|Application ||WB, IHC-P, FC, E|
|Calculated MW||80272 Da|
|Antigen Region||128-155 aa|
|Other Names||Probable ATP-dependent RNA helicase DDX17, DEAD box protein 17, DEAD box protein p72, RNA-dependent helicase p72, DDX17|
|Target/Specificity||This DDX17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-155 amino acids from the N-terminal region of human DDX17.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DDX17 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.|
|Cellular Location||Nucleus. Nucleus, nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
DDX17 box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and splicesosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This protein encodes a DEAD box protein, which is an ATPase activated by a variety of RNA species, but not by dsDNA. This protein, and that encoded by DDX5 gene, are more closely related to each other than to any other member of the DEAD box family.
Wortham,N.C., et.al., Oncogene 28 (46), 4053-4064 (2009)
Tonevitsky,E.A., et.al., Bull. Exp. Biol. Med. 147 (6), 733-736 (2009)
Wong,H.Y., et.al., Biochim. Biophys. Acta 1794 (2), 193-198 (2009)
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