|Application ||WB, IHC-P, FC, E|
|Calculated MW||37681 Da|
|Antigen Region||1-30 aa|
|Other Names||Meiotic recombination protein DMC1/LIM15 homolog, DMC1, DMC1H, LIM15|
|Target/Specificity||This DMC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DMC1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DMC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|
|Cellular Location||Nucleus. Chromosome|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
DMC1 is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this protein is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes.
Volodin,A.A. J. Biol. Chem. 284 (3), 1495-1504 (2009)
Hikiba,J.FEBS J. 276 (2), 457-465 (2009)
Hikiba,J. Nucleic Acids Res. 36 (12), 4181-4190 (2008)
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