DMC1 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| FC, IHC-P, WB, E |
---|---|
Primary Accession | Q14565 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 37681 Da |
Antigen Region | 1-30 aa |
Gene ID | 11144 |
---|---|
Other Names | Meiotic recombination protein DMC1/LIM15 homolog, DMC1, DMC1H, LIM15 |
Target/Specificity | This DMC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human DMC1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | DMC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | DMC1 |
---|---|
Synonyms | DMC1H, LIM15 |
Function | Participates in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q61880}. Chromosome {ECO:0000250|UniProtKB:Q61880} |
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Provided below are standard protocols that you may find useful for product applications.
Background
DMC1 is essential for meiotic homologous recombination. Genetic recombination in meiosis plays an important role in generating diversity of genetic information. The product of this protein is structurally and evolutionary related to the products of the yeast RAD51 and E. coli RecA genes.
References
Volodin,A.A. J. Biol. Chem. 284 (3), 1495-1504 (2009)
Hikiba,J.FEBS J. 276 (2), 457-465 (2009)
Hikiba,J. Nucleic Acids Res. 36 (12), 4181-4190 (2008)
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