|Application ||WB, FC, E|
|Other Accession||Q812E9, P35802, Q0VD07|
|Predicted||Bovine, Mouse, Rat|
|Calculated MW||31210 Da|
|Antigen Region||232-259 aa|
|Other Names||Neuronal membrane glycoprotein M6-a, M6a, GPM6A, M6A|
|Target/Specificity||This GPM6A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-259 amino acids from the C-terminal region of human GPM6A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GPM6A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G- protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendritic spine Cell projection, filopodium. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons. Localized to the growth cone edge membrane of elongating axons (By similarity).|
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Michibata,H. Stem Cells Dev. 18 (4), 629-639 (2009) Boks,M.P. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (6), 707-711 (2008) Liang,Y.J. Cell Res. 18 (7), 768-779 (2008)
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