|Application ||WB, FC, E|
|Calculated MW||38953 Da|
|Antigen Region||174-200 aa|
|Other Names||Galanin receptor type 1, GAL1-R, GALR-1, GALR1, GALNR, GALNR1|
|Target/Specificity||This GALR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 174-200 amino acids from the Central region of human GALR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GALR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
GALR1 elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart.
Borroto-Escuela,D.O. Biochem. Biophys. Res. Commun. 393 (4), 767-772 (2010)
Gratacos,M. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816
Marroni,F. Circ Cardiovasc Genet 2 (4), 322-328 (2009)
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