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TCHP Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TCHP Antibody (Center) AP9354c
    Western blot analysis of TCHP Antibody (Center) (Cat. #AP9354c) in CEM cell line lysates (35ug/lane). TCHP (arrow) was detected using the purified Pab.
  • IHC-P - TCHP Antibody (Center) AP9354c
    Formalin-fixed and paraffin-embedded human skin tissue reacted with TCHP Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - TCHP Antibody (Center) AP9354c
    TCHP Antibody (Center) (Cat. #AP9354c) flow cytometric analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BT92
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 61072 Da
Antigen Region 291-320 aa
Additional Information
Gene ID 84260
Other Names Trichoplein keratin filament-binding protein, Protein TCHP, Mitochondrial protein with oncostatic activity, Mitostatin, Tumor suppressor protein, TCHP {ECO:0000312|EMBL:AAH042851}
Target/Specificity This TCHP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 291-320 amino acids from the Central region of human TCHP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTCHP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCHP {ECO:0000312|EMBL:AAH04285.1}
Function Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.
Cellular Location Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion
Tissue Location Expressed at high levels in normal urothelial and breast epithelial cells. Also expressed in the smooth muscle and endothelial cells. Reduced expression seen in advanced bladder and breast carcinomas (at protein level). Ubiquitous. Expressed at highest levels in the heart, skeletal muscle, kidney, liver and testis.
Research Areas
Citations (0)

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TCHP may act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. This protein may regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells.


Vecchione,A. Oncogene 28 (2), 257-269 (2009)
Tokumasu,F. J. Cell. Sci. 118 (PT 5), 1091-1098 (2005)
Nishizawa,M. J. Cell. Sci. 118 (PT 5), 1081-1090 (2005)

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$ 295.00
$ 99.00
Cat# AP9354c
(40 western blots)
Availability: In Stock
Bulk Size
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