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PPIC Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| FC, IHC-P, WB, E |
|---|---|
| Primary Accession | P45877 |
| Other Accession | Q08E11 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22763 Da |
| Antigen Region | 61-89 aa |
| Gene ID | 5480 |
|---|---|
| Other Names | Peptidyl-prolyl cis-trans isomerase C, PPIase C, Cyclophilin C, Rotamase C, PPIC, CYPC |
| Target/Specificity | This PPIC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-89 amino acids from the Central region of human PPIC. |
| Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PPIC Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | PPIC (HGNC:9256) |
|---|---|
| Synonyms | CYPC |
| Function | PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:P30412}. |
| Tissue Location | Expressed in kidney, skeletal muscle, pancreas, heart, lung, liver and to a lower extent in brain |
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Provided below are standard protocols that you may find useful for product applications.
Background
PPIC is a member of the peptidyl-prolyl cis-trans isomerase (PPIase)) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. Similar to other PPIases, this protein can bind immunosuppressant cyclosporin A.
References
Vasan,R.S. JAMA 302 (2), 168-178 (2009)
Lim,J. Cell 125 (4), 801-814 (2006)
Trahey,M. Proc. Natl. Acad. Sci. U.S.A. 96 (6), 3006-3011 (1999)
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