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IMP4 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IMP4 Antibody (C-term) AP9358b
    All lanes : Anti-IMP4 Antibody (C-term) at 1:1000 dilution Lane 1: Hela whole cell lysate Lane 2: HepG2 whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 34 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IHC-P - IMP4 Antibody (C-term) AP9358b
    IMP4 Antibody (C-term) (Cat. #AP9358b) IHC analysis in formalin fixed and paraffin embedded human testis carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the IMP4 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, IHC-P, E
Primary Accession Q96G21
Other Accession Q5PQR5, Q8VHZ7
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 215-243 aa
Additional Information
Other Names U3 small nucleolar ribonucleoprotein protein IMP4, U3 snoRNP protein IMP4, Brix domain-containing protein 4, IMP4, BXDC4
Target/Specificity This IMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the C-terminal region of human IMP4.
Dilution WB~~1:1000
IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIMP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IMP4
Synonyms BXDC4
Function Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.
Cellular Location Nucleus, nucleolus EMBL; AY364245; AAQ76804.1; -; mRNA EMBL; AK289878; BAF82567.1; -; mRNA EMBL; AK292345; BAF85034.1; -; mRNA EMBL; AK312808; BAG35666.1; -; mRNA EMBL; AC132479; AAY24076.1; -; Genomic_DNA EMBL; BC010042; AAH10042.1; -; mRNA CCDS; CCDS2160.1; - RefSeq; NP_001307233.1; NM_001320304.1 RefSeq; NP_001307234.1; NM_001320305.1 RefSeq; NP_001307235.1; NM_001320306.1 RefSeq; NP_001307236.1; NM_001320307.1 RefSeq; NP_001307238.1; NM_001320309.1 RefSeq; NP_001307239.1; NM_001320310.1 RefSeq; NP_001307240.1; NM_001320311.1 RefSeq; NP_219484.1; NM_033416.2 UniGene; Hs.91579; - ProteinModelPortal; Q96G21; - SMR; Q96G21; - BioGrid; 124984; 35 CORUM; Q96G21; - IntAct; Q96G21; 3 MINT; Q96G21; - STRING; 9606.ENSP00000259239; - iPTMnet; Q96G21; - PhosphoSitePlus; Q96G21; - BioMuta; IMP4; - DMDM; 73621060; - EPD; Q96G21; - MaxQB; Q96G21; - PaxDb; Q96G21; - PeptideAtlas; Q96G21; - PRIDE; Q96G21; - ProteomicsDB; 76583; - DNASU; 92856; - Ensembl; ENST00000259239; ENSP00000259239; ENSG00000136718 GeneID; 92856; - KEGG; hsa:92856; - UCSC; uc002tra.2; human CTD; 92856; - EuPathDB; HostDB:ENSG00000136718.9; - GeneCards; IMP4; - HGNC; HGNC:30856; IMP4 HPA; HPA066222; - HPA; HPA066673; - MIM; 612981; gene neXtProt; NX_Q96G21; - OpenTargets; ENSG00000136718; - PharmGKB; PA142671656; - eggNOG; KOG2781; Eukaryota eggNOG; COG2136; LUCA GeneTree; ENSGT00550000074987; - HOGENOM; HOG000172063; - HOVERGEN; HBG056795; - InParanoid; Q96G21; - KO; K14561; - OMA; FFNISDV; - OrthoDB; EOG091G0GP1; - PhylomeDB; Q96G21; - TreeFam; TF300016; - Reactome; R-HSA-6790901; rRNA modification in the nucleus and cytosol Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol ChiTaRS; IMP4; human GeneWiki; IMP4; - GenomeRNAi; 92856; - PRO; PR:Q96G21; - Proteomes; UP000005640; Chromosome 2 Bgee; ENSG00000136718; - CleanEx; HS_IMP4; - ExpressionAtlas; Q96G21; baseline and differential Genevisible; Q96G21; HS GO; GO:0001650; C:fibrillar center; IDA:HPA GO; GO:0034457; C:Mpp10 complex; IDA:MGI GO; GO:0005730; C:nucleolus; IDA:HGNC GO; GO:0005654; C:nucleoplasm; TAS:Reactome GO; GO:0030684; C:preribosome; IDA:MGI GO; GO:0032040; C:small-subunit processome; IBA:GO_Central GO; GO:0042134; F:rRNA primary transcript binding; IBA:GO_Central GO; GO:0030515; F:snoRNA binding; IBA:GO_Central GO; GO:0006364; P:rRNA processing; IBA:GO_Central InterPro; IPR007109; Brix Pfam; PF04427; Brix; 1 SMART; SM00879; Brix; 1 PROSITE; PS50833; BRIX; 1 1: Evidence at protein level; Complete proteome; Nucleus; Reference proteome; Ribonucleoprotein; Ribosome biogenesis; rRNA processing CHAIN 1 291 U3 small nucleolar ribonucleoprotein protein IMP4 /FTId=PRO_0000120236 DOMAIN 83 264 Brix. {ECO:0000255|PROSITE- ProRule:PRU00034} COMPBIAS 3 48 Arg-rich SEQUENCE 291 AA; 33757 MW; 460A05DFFE70C580 CRC64; MLRREARLRR EYLYRKAREE AQRSAQERKE RLRRALEENR LIPTELRREA LALQGSLEFD DAGGEGVTSH VDDEYRWAGV EDPKVMITTS RDPSSRLKMF AKELKLVFPG AQRMNRGRHE VGALVRACKA NGVTDLLVVH EHRGTPVGLI VSHLPFGPTA YFTLCNVVMR HDIPDLGTMS EAKPHLITHG FSSRLGKRVS DILRYLFPVP KDDSHRVITF ANQDDYISFR HHVYKKTDHR NVELTEVGPR FELKLYMIRL GTLEQEATAD VEWRWHPYTN TARKRVFLST E
Citations (0)

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Background

IMP4 forms a ternary complex with IMP3 (MIM 612980) and MPP10 (MPHOSPHO10; MIM 605503) that interacts with U3 small nucleolar RNA (snoRNA), which is required for the early cleavage steps in pre-rRNA processing.

References

Hillier,L.W. Nature 434 (7034), 724-731 (2005)
Andersen,J.S.Nature 433 (7021), 77-83 (2005)
Granneman,S.Nucleic Acids Res. 31 (7), 1877-1887 (2003)

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$ 295.00
$ 99.00
Cat# AP9358b
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(40 western blots)
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