|Application ||WB, IHC-P, E|
|Other Accession||Q5PQR5, Q8VHZ7|
|Calculated MW||33757 Da|
|Antigen Region||215-243 aa|
|Other Names||U3 small nucleolar ribonucleoprotein protein IMP4, U3 snoRNP protein IMP4, Brix domain-containing protein 4, IMP4, BXDC4|
|Target/Specificity||This IMP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 215-243 amino acids from the C-terminal region of human IMP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IMP4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|
|Cellular Location||Nucleus, nucleolus|
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Provided below are standard protocols that you may find useful for product applications.
IMP4 forms a ternary complex with IMP3 (MIM 612980) and MPP10 (MPHOSPHO10; MIM 605503) that interacts with U3 small nucleolar RNA (snoRNA), which is required for the early cleavage steps in pre-rRNA processing.
Hillier,L.W. Nature 434 (7034), 724-731 (2005)
Andersen,J.S.Nature 433 (7021), 77-83 (2005)
Granneman,S.Nucleic Acids Res. 31 (7), 1877-1887 (2003)
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