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SMNDC1 Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SMNDC1 Antibody (N-term) AP9372a
    Western blot analysis of SMNDC1 Antibody (N-term) (Cat. #AP9372a) in mouse kidney tissue lysates (35ug/lane). SMNDC1 (arrow) was detected using the purified Pab.
    detail
  • FC - SMNDC1 Antibody (N-term) AP9372a
    SMNDC1 Antibody (N-term) (Cat. #AP9372a) flow cytometry analysis of 293 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
FC, WB, E
Primary Accession O75940
Other Accession Q4QQU6, Q8BGT7, Q3T045
Reactivity Human, Mouse
Predicted Bovine, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 26711 Da
Antigen Region 11-41 aa
Additional Information
Gene ID 10285
Other Names Survival of motor neuron-related-splicing factor 30, 30 kDa splicing factor SMNrp, SMN-related protein, Survival motor neuron domain-containing protein 1, SMNDC1, SMNR, SPF30
Target/Specificity This SMNDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 11-41 amino acids from the N-terminal region of human SMNDC1.
Dilution WB~~1:1000
FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSMNDC1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SMNDC1
Synonyms SMNR, SPF30
Function Involved in spliceosome assembly.
Cellular Location Nucleus speckle. Nucleus, Cajal body. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies
Tissue Location Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas.
Research Areas
Citations (0)
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Background

This protein is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. The protein encoded by this gene is a nuclear protein that has been identified as a constituent of the spliceosome complex. This protein is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene.

References

Little,J.T. J. Biol. Chem. 283 (13), 8145-8152 (2008)
Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)
Beausoleil,S.A., Nat. Biotechnol. 24 (10), 1285-1292 (2006)

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$ 365.00
$ 140.00
Cat# AP9372a
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