|Application ||IHC-P, WB, E|
|Other Accession||Q62885, Q9Z2R6, Q3SYR2|
|Calculated MW||26962 Da|
|Antigen Region||64-94 aa|
|Other Names||Protein unc-119 homolog A, Retinal protein 4, hRG4, UNC119, RG4|
|Target/Specificity||This UNC119 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-94 amino acids from the Central region of human UNC119.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||UNC119 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in synaptic functions in photoreceptor cells, the signal transduction in immune cells as a Src family kinase activator, endosome recycling, the uptake of bacteria and endocytosis, protein trafficking in sensory neurons and as lipid- binding chaperone with specificity for a diverse subset of myristoylated proteins. Specifically binds the myristoyl moiety of a subset of N-terminally myristoylated proteins and is required for their localization. Binds myristoylated GNAT1 and is required for G-protein localization and trafficking in sensory neurons. Probably plays a role in trafficking proteins in photoreceptor cells. Plays important roles in mediating Src family kinase signals for the completion of cytokinesis via RAB11A.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the centrosome in interphase cells and begins to translocate from the spindle pole to the spindle midzone after the onset of mitosis; it then localizes to the intercellular bridge in telophase cells and to the midbody in cytokinetic cells.|
|Tissue Location||Abundantly expressed in retina, in photoreceptor synapses and inner segments. Expressed in a much lesser extent in several other tissues|
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Provided below are standard protocols that you may find useful for product applications.
UNC119 is specifically expressed in the photoreceptors in the retina. The encoded product shares strong homology with the C. elegans unc119 protein and it can functionally complement the C. elegans unc119 mutation. It has been localized to the photoreceptor synapses in the outer plexiform layer of the retina, and suggested to play a role in the mechanism of photoreceptor neurotransmitter release through the synaptic vesicle cycle.
Karim, Z., et al. Cell. Signal. 22(1):128-137(2010)
Gorska, M.M., et al. J. Immunol. 183(3):1675-1684(2009)
Vepachedu, R., et al. J. Immunol. 179(1):682-690(2007)
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