|Application ||WB, FC, E|
|Calculated MW||50594 Da|
|Antigen Region||214-242 aa|
|Other Names||Plasmalemma vesicle-associated protein, Fenestrated endothelial-linked structure protein, Plasmalemma vesicle protein 1, PV-1, PLVAP, FELS, PV1|
|Target/Specificity||This PLVAP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 214-242 amino acids from the Central region of human PLVAP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PLVAP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability.|
|Cellular Location||Cell membrane; Single-pass type II membrane protein. Membrane, caveola; Single-pass type II membrane protein Cytoplasm, perinuclear region. Note=Membrane- associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region (By similarity).|
|Tissue Location||Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium.|
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Provided below are standard protocols that you may find useful for product applications.
PLVAP involved in the formation of stomatal and fenestral diaphragms of caveolae. This protein may function in microvascular permeability.
Keuschnigg, J., et al. Blood 114(2):478-484(2009)
Carson-Walter, E.B., et al. Clin. Cancer Res. 11(21):7643-7650(2005)
Strickland, L.A., et al. J. Pathol. 206(4):466-475(2005)
Stan, R.V., et al. Mol. Biol. Cell 15(8):3615-3630(2004)
Hnasko, R., et al. J. Endocrinol. 175(3):649-661(2002)
Stan, R.V., et al. Genomics 72(3):304-313(2001)
Stan, R.V., et al. J. Cell Biol. 145(6):1189-1198(1999)
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