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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   CROT Antibody (N-term)   

CROT Antibody (N-term)

Purified Rabbit Polyclonal Antibody (Pab)

  • FC - CROT Antibody (N-term) AP9380a
    CROT Antibody (N-term)(Cat. #AP9380a) flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
  • IHC-P - CROT Antibody (N-term) AP9380a
    Formalin-fixed and paraffin-embedded human brain tissue reacted with CROT Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • WB - CROT Antibody (N-term) AP9380a
    Western blot analysis of CROT Antibody (N-term) (Cat. #AP9380a) in K562 cell line and mouse liver tissue lysates (35ug/lane). CROT (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9UKG9
Reactivity Human, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 70178 Da
Antigen Region 49-79 aa
Additional Information
Gene ID 54677
Other Names Peroxisomal carnitine O-octanoyltransferase, COT, CROT, COT
Target/Specificity This CROT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 49-79 amino acids from the N-terminal region of human CROT.
Dilution FC~~1:10~50
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCROT Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms COT
Function Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester.
Cellular Location Peroxisome.
Research Areas
Citations (0)

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CROT encodes a member of the carnitine/choline acetyltransferase family. The encoded protein converts 4,8-dimethylnonanoyl-CoA to its corresponding carnitine ester. This transesterification occurs in the peroxisome and is necessary for transport of medium- and long- chain acyl-CoA molecules out of the peroxisome to the cytosol and mitochondria. The protein thus plays a role in lipid metabolism and fatty acid beta-oxidation. Alternatively spliced transcript variants have been described.


Li, Y.L., et al. FEBS J. 276(1):303-314(2009)
Morillas, M., et al. J. Biol. Chem. 277(13):11473-11480(2002)
van der Leij, F.R., et al. Mol. Genet. Metab. 71 (1-2), 139-153 (2000) :
Ferdinandusse, S., et al. Biochem. Biophys. Res. Commun. 263(1):213-218(1999)

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$ 295.00
$ 99.00
Cat# AP9380a
(40 western blots)
Availability: In Stock
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