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TBX1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

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  • IHC-P - TBX1 Antibody (C-term) AP9383b
    Immunohistochemical analysis of paraffin-embedded H. breast section using TBX1 Antibody (C-term)(Cat#AP9383b). AP9383b was diluted at 1:25 dilution. A undiluted biotinylated goat polyvalent antibody was used as the secondary, followed by DAB staining.
  • WB - TBX1 Antibody (C-term) AP9383b
    Western blot analysis of lysate from HLVEC cell line, using TBX1 Antibody (C-term) (Cat. #AP9383b). AP9383b was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug.
  • WB - TBX1 Antibody (C-term) AP9383b
    TBX1 Antibody (C-term) (Cat.# AP9383b) western blot analysis in HLVEC cell line lysates (35ug/lane).This demonstrates the TBX1 antibody detected the TBX1 protein (arrow).
  • IF - TBX1 Antibody (C-term) AP9383b
    Fluorescent confocal image of A2058 cell stained with TBX1 Antibody (C-term)(Cat#AP9383b). A2058 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then incubated with TBX1 primary antibody (1:25, 1 h at 37℃). For secondary antibody, Alexa Fluor® 488 conjugated donkey anti-rabbit antibody (green) was used (1:400, 50 min at 37℃).Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7units/ml, 1 h at 37℃). Nuclei were counterstained with DAPI (blue) (10 µg/ml, 10 min). TBX1 immunoreactivity is localized to nucleus significantly.
  • IHC-P - TBX1 Antibody (C-term) AP9383b
    Formalin-fixed and paraffin-embedded human testis tissue reacted with TBX1 Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O43435
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43133 Da
Antigen Region 327-356 aa
Additional Information
Gene ID 6899
Other Names T-box transcription factor TBX1, T-box protein 1, Testis-specific T-box protein, TBX1
Target/Specificity This TBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 327-356 amino acids from the C-terminal region of human TBX1.
Dilution IHC-P~~1:50~100
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTBX1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TBX1
Function Probable transcriptional regulator involved in developmental processes. Is required for normal development of the pharyngeal arch arteries (By similarity).
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00201}
Research Areas
Citations (0)

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TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98% amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.


Fernando, R.I., et al. J. Clin. Invest. 120(2):533-544(2010)
Heike, C.L., et al. Birth Defects Res. Part A Clin. Mol. Teratol. 88(1):54-63(2010)
Beaujard, M.P., et al. Eur J Med Genet 52(5):321-327(2009)
Shalaby, A.A., et al. Mod. Pathol. 22(8):996-1005(2009)
Yamagishi, H., et al. Genes Dev. 17(2):269-281(2003)
Gong, W., et al. J. Med. Genet. 38 (12), E45 (2001) :

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$ 295.00
$ 99.00
Cat# AP9383b
(40 western blots)
Availability: In Stock
Bulk Size
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