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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   CCNB1IP1 Antibody (C-term)   

CCNB1IP1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CCNB1IP1 Antibody (C-term) AP9400b
    Western blot analysis of CCNB1IP1 Antibody (C-term) (Cat. #AP9400b) in NCI-H460 cell line lysates (35ug/lane). CCNB1IP1 (arrow) was detected using the purified Pab.
  • IHC-P - CCNB1IP1 Antibody (C-term) AP9400b
    Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with CCNB1IP1 Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
  • FC - CCNB1IP1 Antibody (C-term) AP9400b
    CCNB1IP1 Antibody (C-term) (Cat. #AP9400b) flow cytometry analysis of NCI-H460 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NPC3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31544 Da
Antigen Region 199-228 aa
Additional Information
Gene ID 57820
Other Names E3 ubiquitin-protein ligase CCNB1IP1, 632-, Cyclin-B1-interacting protein 1, Human enhancer of invasion 10, CCNB1IP1, C14orf18, HEI10
Target/Specificity This CCNB1IP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the C-terminal region of human CCNB1IP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCNB1IP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms C14orf18, HEI10
Function Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non-crossover sites. Later, it is directed by MutL- gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis.
Cellular Location Nucleus. Chromosome. Note=Associates to the synaptonemal complex
Tissue Location Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung.
Research Areas
Citations (0)

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HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.


Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Gronholm, M., et al. Oncogene 25(32):4389-4398(2006)
Toby, G.G., et al. Mol. Cell. Biol. 23(6):2109-2122(2003)

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$ 295.00
$ 99.00
Cat# AP9400b
(40 western blots)
Availability: In Stock
Bulk Size
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