CCNB1IP1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, IHC-P, FC, E |
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Primary Accession | Q9NPC3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 31544 Da |
Antigen Region | 199-228 aa |
Gene ID | 57820 |
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Other Names | E3 ubiquitin-protein ligase CCNB1IP1, 632-, Cyclin-B1-interacting protein 1, Human enhancer of invasion 10, CCNB1IP1, C14orf18, HEI10 |
Target/Specificity | This CCNB1IP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 199-228 amino acids from the C-terminal region of human CCNB1IP1. |
Dilution | WB~~1:1000 IHC-P~~1:50~100 FC~~1:10~50 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CCNB1IP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CCNB1IP1 |
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Synonyms | C14orf18, HEI10 |
Function | Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non- crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over (By similarity). Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. |
Cellular Location | Nucleus. Chromosome. Note=Associates to the synaptonemal complex |
Tissue Location | Highly expressed in heart. Detected at intermediate levels in liver and kidney, and at low levels in placenta, brain and lung. |
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Provided below are standard protocols that you may find useful for product applications.
Background
HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M.
References
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Gronholm, M., et al. Oncogene 25(32):4389-4398(2006)
Toby, G.G., et al. Mol. Cell. Biol. 23(6):2109-2122(2003)
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