|Application ||WB, IHC-P, FC, E|
|Other Accession||Q8C2S5, A2VE78|
|Calculated MW||78555 Da|
|Antigen Region||86-115 aa|
|Other Names||F-box/LRR-repeat protein 5, F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, p45SKP2-like protein, FBXL5, FBL4, FBL5, FLR1|
|Target/Specificity||This FBXL5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 86-115 amino acids from the N-terminal region of human FBXL5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXL5 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FBL4, FBL5, FLR1|
|Function||Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.|
|Cellular Location||Cytoplasm, perinuclear region|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Salahudeen, A.A., et al. Science 326(5953):722-726(2009)
Vashisht, A.A., et al. Science 326(5953):718-721(2009)
Zhang, N., et al. Biochem. Biophys. Res. Commun. 359(1):34-39(2007)
Ilyin, G.P., et al. Genomics 67(1):40-47(2000)
Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)
Cenciarelli, C., et al. Curr. Biol. 9(20):1177-1179(1999)
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