|Application ||WB, IHC-P, E|
|Other Accession||P63041, P63040, Q4R4N1, Q0IIL7|
|Predicted||Bovine, Monkey, Mouse, Rat|
|Calculated MW||15030 Da|
|Antigen Region||33-60 aa|
|Other Names||Complexin-1, Complexin I, CPX I, Synaphin-2, CPLX1|
|Target/Specificity||This CPLX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-60 amino acids from the Central region of human CPLX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CPLX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).|
|Cellular Location||Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons|
|Tissue Location||Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CPLX1 encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.
Salimi, K., et al. Synapse 62(4):273-282(2008)
Giraudo, C.G., et al. Science 313(5787):676-680(2006)
Kishi, T., et al. Schizophr. Res. 82 (2-3), 185-189 (2006) :
Basso, M., et al. Proteomics 4(12):3943-3952(2004)
Chen, X., et al. Neuron 33(3):397-409(2002)
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