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CPLX1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CPLX1 Antibody (Center) AP9412c
    Anti-CPLX1 Antibody (Center) at 1:1000 dilution + mouse brain lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 15 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IHC-P - CPLX1 Antibody (Center) AP9412c
    Formalin-fixed and paraffin-embedded human brain tissue reacted with CPLX1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O14810
Other Accession P63041, P63040, Q4R4N1, Q0IIL7
Reactivity Mouse
Predicted Bovine, Monkey, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 15030 Da
Antigen Region 33-60 aa
Additional Information
Gene ID 10815
Other Names Complexin-1, Complexin I, CPX I, Synaphin-2, CPLX1
Target/Specificity This CPLX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 33-60 amino acids from the Central region of human CPLX1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCPLX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CPLX1
Function Positively regulates a late step in synaptic vesicle exocytosis. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells (By similarity).
Cellular Location Cytoplasm, cytosol. Note=Enriched at synaptic-releasing sites in mature neurons
Tissue Location Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease
Research Areas
Citations (0)

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CPLX1 encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release.


Salimi, K., et al. Synapse 62(4):273-282(2008)
Giraudo, C.G., et al. Science 313(5787):676-680(2006)
Kishi, T., et al. Schizophr. Res. 82 (2-3), 185-189 (2006) :
Basso, M., et al. Proteomics 4(12):3943-3952(2004)
Chen, X., et al. Neuron 33(3):397-409(2002)

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$ 295.00
$ 99.00
Cat# AP9412c
(40 western blots)
Availability: In Stock
Bulk Size
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