|Application ||WB, E|
|Calculated MW||105532 Da|
|Antigen Region||106-135 aa|
|Other Names||Anoctamin-7, Dresden transmembrane protein of the prostate, D-TMPP, IPCA-5, New gene expressed in prostate, Prostate cancer-associated protein 5, Transmembrane protein 16G, ANO7, NGEP, PCANAP5, TMEM16G|
|Target/Specificity||This ANO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human ANO7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANO7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NGEP, PCANAP5, TMEM16G|
|Function||Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.|
|Cellular Location||Isoform 1: Cell membrane; Multi- pass membrane protein. Cell junction. Endoplasmic reticulum. Note=Concentrates at sites of cell- cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604|
|Tissue Location||Specifically expressed in epithelial cells of the prostate (at protein level).|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ANO7 may act as a calcium-activated chloride channel. This protein May play a role in cell-cell interactions.
Cereda, V., et al. Cancer Immunol. Immunother. 59(1):63-71(2010)
Hartzell, H.C., et al. J. Physiol. (Lond.) 587 (PT 10), 2127-2139 (2009)
Das, S., et al. Cancer Res. 68(15):6306-6312(2008)
Kiessling, A., et al. Prostate 64(4):387-400(2005)
Katoh, M., et al. Int. J. Mol. Med. 14(4):759-764(2004)
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