ANO7 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q6IWH7 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 105532 Da |
Antigen Region | 106-135 aa |
Gene ID | 50636 |
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Other Names | Anoctamin-7, Dresden transmembrane protein of the prostate, D-TMPP, IPCA-5, New gene expressed in prostate, Prostate cancer-associated protein 5, Transmembrane protein 16G, ANO7, NGEP, PCANAP5, TMEM16G |
Target/Specificity | This ANO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human ANO7. |
Dilution | WB~~1:2000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | ANO7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | ANO7 |
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Synonyms | NGEP, PCANAP5, TMEM16G |
Function | Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693). May play a role in cell-cell interactions (PubMed:17308099). |
Cellular Location | [Isoform 1]: Cell membrane; Multi-pass membrane protein. Cell junction. Endoplasmic reticulum. Note=Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604 |
Tissue Location | Specifically expressed in epithelial cells of the prostate (at protein level). |
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Provided below are standard protocols that you may find useful for product applications.
Background
ANO7 may act as a calcium-activated chloride channel. This protein May play a role in cell-cell interactions.
References
Cereda, V., et al. Cancer Immunol. Immunother. 59(1):63-71(2010)
Hartzell, H.C., et al. J. Physiol. (Lond.) 587 (PT 10), 2127-2139 (2009)
Das, S., et al. Cancer Res. 68(15):6306-6312(2008)
Kiessling, A., et al. Prostate 64(4):387-400(2005)
Katoh, M., et al. Int. J. Mol. Med. 14(4):759-764(2004)
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