|Application ||WB, E|
|Calculated MW||105532 Da|
|Antigen Region||106-135 aa|
|Other Names||Anoctamin-7, Dresden transmembrane protein of the prostate, D-TMPP, IPCA-5, New gene expressed in prostate, Prostate cancer-associated protein 5, Transmembrane protein 16G, ANO7, NGEP, PCANAP5, TMEM16G|
|Target/Specificity||This ANO7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-135 amino acids from the N-terminal region of human ANO7.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ANO7 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||NGEP, PCANAP5, TMEM16G|
|Function||Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium- activated chloride channel (CaCC) activity. May play a role in cell-cell interactions.|
|Cellular Location||Isoform 1: Cell membrane; Multi- pass membrane protein. Cell junction. Endoplasmic reticulum. Note=Concentrates at sites of cell- cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604|
|Tissue Location||Specifically expressed in epithelial cells of the prostate (at protein level).|
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Provided below are standard protocols that you may find useful for product applications.
ANO7 may act as a calcium-activated chloride channel. This protein May play a role in cell-cell interactions.
Cereda, V., et al. Cancer Immunol. Immunother. 59(1):63-71(2010)
Hartzell, H.C., et al. J. Physiol. (Lond.) 587 (PT 10), 2127-2139 (2009)
Das, S., et al. Cancer Res. 68(15):6306-6312(2008)
Kiessling, A., et al. Prostate 64(4):387-400(2005)
Katoh, M., et al. Int. J. Mol. Med. 14(4):759-764(2004)
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