|Application ||WB, E|
|Calculated MW||46737 Da|
|Antigen Region||158-187 aa|
|Other Names||Alpha-1-antitrypsin, Alpha-1 protease inhibitor, Alpha-1-antiproteinase, Serpin A1, Short peptide from AAT, SPAAT, SERPINA1, AAT, PI|
|Target/Specificity||This SERPINA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 158-187 amino acids from the Central region of human SERPINA1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SERPINA1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin.|
|Cellular Location||Secreted. Endoplasmic reticulum. Note=The S and Z allele are not secreted effectively and accumulate intracellularly in the endoplasmic reticulum|
|Tissue Location||Ubiquitous. Expressed in leukocytes and plasma.|
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Provided below are standard protocols that you may find useful for product applications.
SERPINA1 is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema or liver disease.
Kilty, S.J., et al. Am J Rhinol Allergy 24 (1), E4-E9 (2010)
Kok, K.F., et al. BMC Gastroenterol 10, 22 (2010)
Dahl, M. Clin Respir J 3(2):121-122(2009)
Zhang, H., et al. Nat. Biotechnol. 21(6):660-666(2003)
Mills, K., et al. Glycobiology 13(2):73-85(2003)
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