|Application ||WB, E|
|Calculated MW||56598 Da|
|Antigen Region||186-214 aa|
|Other Names||Neutral amino acid transporter B(0), ATB(0), Baboon M7 virus receptor, RD114/simian type D retrovirus receptor, Sodium-dependent neutral amino acid transporter type 2, Solute carrier family 1 member 5, SLC1A5, ASCT2, M7V1, RDR, RDRC|
|Target/Specificity||This SLC1A5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 186-214 amino acids from the Central region of human SLC1A5.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC1A5 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||ASCT2, M7V1, RDR, RDRC|
|Function||Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development (PubMed:10708449, PubMed:23492904). Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses (PubMed:10051606, PubMed:10196349).|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV|
|Tissue Location||Placenta, lung, skeletal muscle, kidney, pancreas, and intestine|
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Provided below are standard protocols that you may find useful for product applications.
SLC1A5 (Solute carrier family 1 (neutral amino acid transporter), member 5) is a member of the Na(+)-dependent amino acid transporter superfamily. It has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. It acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses.
# Crowther-Swanepoel, D., et al. Nat. Genet. 42(2):132-136(2010)
# Wich, C., et al. Gynecol. Obstet. Invest. 68(1):9-18(2009)
# Avissar, N.E., et al. Dig. Dis. Sci. 53(8):2113-2125(2008)
# Broer, S. Physiol. Rev. 88(1):249-286(2008)
# Deng, X., et al. BMC Psychiatry 8, 58 (2008)
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