|Application ||WB, E|
|Calculated MW||60811 Da|
|Antigen Region||265-292 aa|
|Other Names||Integral membrane protein DGCR2/IDD, DGCR2, IDD, KIAA0163|
|Target/Specificity||This DGCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 265-292 amino acids from the Central region of human DGCR2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DGCR2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative adhesion receptor, that could be involved in cell-cell or cell-matrix interactions required for normal cell differentiation and migration.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
|Tissue Location||Predominantly expressed in brain, heart, lung and fetal kidney. Low levels in liver and adult kidney|
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Provided below are standard protocols that you may find useful for product applications.
DGCR2 encodes a novel putative adhesion receptor protein, which could play a role in neural crest cells migration, a process which has been proposed to be altered in DiGeorge syndrome.
Georgi, A., et al. Psychiatr. Genet. 19 (2), 104 (2009)
Wang, P., et al. BMC Genomics 10, 518 (2009)
Ishiguro, H., et al. Psychiatr. Genet. 18(5):255-256(2008)
Pellikka, M., et al. J. Thromb. Thrombolysis 26(2):91-96(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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