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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   HAMP Antibody (Center)   

HAMP Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - HAMP Antibody (Center) AP9459C
    Anti-HAMP Antibody (Center) at 1:500 dilution + human liver lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 9 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • WB - HAMP Antibody (Center) AP9459C
    Western blot analysis of HAMP Antibody (Center) (Cat. #AP9459c) in MDA-MB435 cell line lysates (35ug/lane). HAMP (arrow) was detected using the purified Pab.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P81172
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 9408 Da
Antigen Region 17-46 aa
Additional Information
Gene ID 57817
Other Names Hepcidin, Liver-expressed antimicrobial peptide 1, LEAP-1, Putative liver tumor regressor, PLTR, Hepcidin-25, Hepc25, Hepcidin-20, Hepc20, HAMP, HEPC, LEAP1
Target/Specificity This HAMP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 17-46 amino acids from the Central region of human HAMP.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHAMP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms HEPC, LEAP1
Function Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes (PubMed:22306005).
Cellular Location Secreted.
Tissue Location Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland Secreted into the urine.
Research Areas
Citations (0)

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HAMP is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in macrophages, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize their beta-sheet structures. These peptides exhibit antimicrobial activity.


Matsumoto, M., et al. Circ. J. 74(2):301-306(2010)
del Giudice, E.M., et al. J. Clin. Endocrinol. Metab. 94(12):5102-5107(2009)
Kwapisz, J., et al. J Zhejiang Univ Sci B 10(11):791-795(2009)
Barton, J.C., et al. Am. J. Hematol. 84(11):710-714(2009)
Nemeth, E., et al. Acta Haematol. 122 (2-3), 78-86 (2009)
Hunter, H.N., et al. J. Biol. Chem. 277(40):37597-37603(2002)
Kluver, E., et al. J. Pept. Res. 59(6):241-248(2002)

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$ 295.00
$ 99.00
Cat# AP9459C
(40 western blots)
Availability: In Stock
Bulk Size
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