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ITA6 AntibodyPeptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP9460d | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP9460d-ev20 | Ev20 size 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
- Reviews
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- Backgrounds
ITA6 Antibody - Product info | |
| Application | WB
|
| Primary Accession | P23229 |
| Reactivity | Human |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 126633 Da |
ITA6 Antibody - Additional info | |
| Gene ID 3655 | |
| Other Names ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD_antigen=CD49f; Integrin alpha-6 heavy chain; Integrin alpha-6 light chain | |
| Target/Specificity This ITA6 antibody is generated from rabbits immunized with ITA6 recombinant protein. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions ITA6 Antibody is for research use only and not for use in diagnostic or therapeutic procedures. | |
ITA6 Antibody - Protein Information | |
| Name ITGA6 | |
| Function Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome | |
| Cellular Location Cell membrane; Single-pass type I membrane protein | |
| Tissue Location Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney) | |
ITA6 Antibody - Related products
AP2753a: ITGA6 Antibody (isoform 2 S1064)
AP3687a: Phospho-ITGA6 iso2-pS1064 Antibody
AP9255b: CD49f Antibody (C-term)
RI12782: ITGA6 predesign siRNA
BP2753a: ITGA6 Antibody (isoform 2 S1064) Blocking Peptide
BP3687a: Phospho-ITGA6 iso2-pS1064 Antibody Blocking Peptide
ITA6 Antibody - Application data
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Western blot analysis of ITA6 Antibody (Cat. #AP9460d) in MDA-MB231 cell line lysates (35ug/lane). ITA6 (arrow) was detected using the purified Pab.
ITA6 Antibody - Research Areas
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BACKGROUND
The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
REFERENCES
Kim, T.H., et al. Mol. Cancer Res. 7(10):1605-1612(2009) Eeles, R.A., et al. Nat. Genet. 41(10):1116-1121(2009) Boroujerdnia, M.G., et al. Pak. J. Biol. Sci. 12(4):360-366(2009) Dai, J.Y., et al. BMC Cancer 9, 337 (2009) Dydensborg, A.B., et al. BMC Cancer 9, 223 (2009)
